Bak Lab

Publications

Rasmus O. Bak on Google Scholar profile

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Martin RM, Ikeda K, Cromer MK, Uchida N, Nishimura T, Romano R et al. Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination. Cell Stem Cell. 2019 May 2;24(5):821-828.e5. doi: 10.1016/j.stem.2019.04.001
Bak R, Dever DP, Porteus MH. CRISPR/Cas9 genome editing in human hematopoietic stem cells. Nature Protocols (Print). 2018;13(2):358-376. doi: 10.1038/nprot.2017.143
Bak RO, Gomez-Ospina N, Porteus MH. Gene Editing on Center Stage. Trends in Genetics. 2018;34(8):600-611. doi: 10.1016/j.tig.2018.05.004
Bak RO, Dever DP, Porteus MH. Therapeutic Genome Editing in Human Hematopoietic Stem and Progenitor Cells. In Genome Editing and Engineering: From TALENs, ZFNs and CRISPRs to Molecular Surgery. Cambridge University Press. 2018. p. 301-312 doi: 10.1017/9781316756300.022
Charlesworth CT, Camarena J, Cromer MK, Vaidyanathan S, Bak RO, Carte JM et al. Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene Targeting. Molecular Therapy - Nucleic Acids. 2018 Sept 7;12:89-104. doi: 10.1016/j.omtn.2018.04.017
Cromer MK, Vaidyanathan S, Ryan DE, Curry B, Lucas AB, Camarena J et al. Global Transcriptional Response to CRISPR/Cas9-AAV6-Based Genome Editing in CD34 Hematopoietic Stem and Progenitor Cells. Molecular Therapy. 2018;26(10):2431-2442. doi: 10.1016/j.ymthe.2018.06.002
Dalsgaard T, Kaadt CRC, Askou AL, Bak RO, Andersen PO, Hougaard D et al. Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein. Molecular Therapy - Nucleic Acids. 2018 Sept 7;12:672-683. Epub 2018 Aug 6. doi: 10.1016/j.omtn.2018.07.005
Hollensen AK, Andersen S, Hjorth K, Bak RO, Hansen TB, Kjems J et al. Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs. Molecular Therapy - Nucleic Acids. 2018 Dec 7;13:365-375. Epub 2018 Sept 21. doi: 10.1016/j.omtn.2018.09.009
Laustsen A, Bak R, Krapp C, Kjær L, Egedahl JH, Petersen CC et al. Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function. Nature Communications. 2018 Aug 30;9(1):3525. doi: 10.1038/s41467-018-05816-y
Skipper KA, Nielsen MG, Andersen S, Ryø LB, Bak RO, Mikkelsen JG. Time-Restricted PiggyBac DNA Transposition by Transposase Protein Delivery Using Lentivirus-Derived Nanoparticles. Molecular Therapy - Nucleic Acids. 2018 Jun 1;11:253-262. doi: 10.1016/j.omtn.2018.02.006
Vakulskas CA, Dever DP, Rettig GR, Turk R, Jacobi AM, Collingwood MA et al. A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells. Nature Medicine. 2018;24(8):1216-1224. doi: 10.1038/s41591-018-0137-0
Bak RO, Porteus MH. CRISPR-Mediated Integration of Large Gene Cassettes Using AAV Donor Vectors. Cell Reports. 2017 Jul 18;20(3):750-756. doi: 10.1016/j.celrep.2017.06.064
Bak RO, Dever DP, Reinisch A, Cruz Hernandez D, Majeti R, Porteus MH. Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6. eLife. 2017 Sept 28;6:e27873. doi: 10.7554/eLife.27873
Hollensen AK, Thomsen R, Bak RO, Petersen CC, Ermegaard ER, Aagaard L et al. Improved microRNA suppression by WPRE-linked Tough Decoy microRNA sponges. RNA. 2017 Aug;23(8):1247-1258. Epub 2017 May 9. doi: 10.1261/rna.061192.117
Dever DP, Bak RO, Reinisch A, Camarena J, Washington G, Nicolas CE et al. CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells. Nature. 2016 Nov 17;539(7629):384-389. doi: 10.1038/nature20134
Hnisz D, Weintraub AS, Day DS, Valton AL, Bak RO, Li CH et al. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science. 2016 Mar 25;351(6280):1454-1458. doi: 10.1126/science.aad9024
Holm CK, Rahbek SH, Gad HH, Bak RO, Jakobsen MR, Jiang Z et al. Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses. Nature Communications. 2016 Feb 19;7:10680. doi: 10.1038/ncomms10680
Hendel A, Bak RO, Clark JT, Kennedy AB, Ryan DE, Roy S et al. Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells. Nature Biotechnology. 2015 Jun 29. doi: 10.1038/nbt.3290
Rasmussen TK, Andersen T, Bak RO, Yiu G, Sørensen C, Stengaard-Pedersen K et al. Overexpression of MicroRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus. Arthritis research & therapy. 2015 Jun 9;17(1):154. doi: 10.1186/s13075-015-0660-z
Cai Y, Bak R, Mikkelsen JG. Targeted genome editing by lentiviral protein transduction of zinc-finger and TAL-effector nucleases. eLife. 2014 Apr 24;3:e01911. doi: 10.7554/eLife.01911
Bak RO, Hollensen AK, Mikkelsen JG. Managing MicroRNAs with Vector-Encoded Decoy-Type Inhibitors. Molecular Therapy. 2013 Aug;21(8):1478-85. doi: 10.1038/mt.2013.113
Bak R, Mikkelsen JG. miRNA sponges: soaking up miRNAs for regulation of gene expression. Wiley Interdisciplinary Reviews: RNA. 2013 Dec 23. doi: 10.1002/wrna.1213
Bak RO, Hollensen AK, Primo MN, Sørensen CD, Mikkelsen JG. Potent microRNA suppression by RNA Pol II-transcribed 'Tough Decoy' inhibitors. RNA. 2013;19(2):280-293. doi: 10.1261/rna.034850.112
Cai Y, Bak RO, Krogh LB, Staunstrup NH, Moldt B, Corydon TJ et al. DNA transposition by protein transduction of the piggyBac transposase from lentiviral Gag precursors. Nucleic Acids Research. 2013 Nov 21. doi: 10.1093/nar/gkt1163
Hollensen AK, Bak RO, Haslund D, Mikkelsen JG. Suppression of microRNAs by dual-targeting and clustered Tough Decoy inhibitors. RNA Biology. 2013;10(3).
Jakobsen MR, Bak RO, Andersen A, Berg RK, Jensen SB, Tengchuan J et al. IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. Proceedings of the National Academy of Sciences (PNAS). 2013 Oct 23. doi: 10.1073/pnas.1311669110
Kofod-Olsen E, Møller JM, Schleimann MH, Bundgaard B, Bak RO, Øster B et al. Inhibition of p53-dependent, but not p53-independent, cell death by U19 protein from human herpesvirus 6B. PLoS One. 2013;8(e59223):1-11.
Sharma N, Cai Y, Bak RO, Jakobsen MR, Schrøder LD, Mikkelsen JG. Efficient sleeping beauty DNA transposition from DNA minicircles. Molecular Therapy - Nucleic Acids. 2013;2:e74. doi: 10.1038/mtna.2013.1
Staunstrup NH, Bak RO, Cai Y, Svensson L, Petersen AT, Rosada C et al. A lentiviral vector-based genetic sensor system for comparative analysis of permeability and activity of vitamin D3 analogues in xenotransplanted human skin. Experimental Dermatology. 2013 Mar 22;22(3):178-83. doi: 10.1111/exd.12091
Nascimento Lopes Primo M, Bak RO, Mikkelsen JG. Lentiviral vectors for cutaneous RNA managing. Experimental Dermatology. 2012;21(3):162-70. doi: 10.1111/j.1600-0625.2011.01436.x
Nascimento Primo M, Bak RO, Schibler B, Mikkelsen JG. Regulation of pro-inflammatory cytokines TNFα and IL24 by microRNA-203 in primary keratinocytes. Cytokine. 2012. doi: 10.1016/j.cyto.2012.07.031
Sharma N, Hollensen AK, Bak RO, Staunstrup NH, Schrøder LD, Mikkelsen JG. The Impact of cHS4 Insulators on DNA Transposon Vector Mobilization and Silencing in Retinal Pigment Epithelium Cells. PLoS One. 2012;7(10). doi: 10.1371/journal.pone.0048421
Bak RO, Mikkelsen JG. Mobilization of DNA transposable elements from lentiviral vectors. Mobile Genetic Elements. 2011 Jul;1(2):139-144.
Bak RO, Stenderup K, Rosada C, Petersen LB, Moldt B, Dagnæs-Hansen F et al. Targeting of human interleukin-12B by small hairpin RNAs in xenografted psoriatic skin. BMC Dermatology. 2011 Feb 27;11(1):5. doi: 10.1186/1471-5945-11-5
Moldt B, Miskey C, Staunstrup NH, Gogol-Döring A, Bak RO, Sharma N et al. Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells. Molecular Therapy. 2011 Aug;19(8).
Staunstrup NH, Sharma N, Bak RO, Svensson L, Petersen TK, Aarenstrup L et al. A Sleeping Beauty DNA transposon-based genetic sensor for functional screening of vitamin D3 analogues. BMC Biotechnology. 2011 Apr 7;11(1):33. doi: 10.1186/1472-6750-11-33
Bak RO, Mikkelsen JG. Regulation of cytokines by small RNAs during skin inflammation. Journal of Biomedical Science. 2010;17(53).

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Revised 26.03.2026
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Rasmus O. Bak