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Bak Lab

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Vakulskas CA, Dever DP, Rettig GR, Turk R, Jacobi AM, Collingwood MA et al. A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells. Nature Medicine. 2018;24(8):1216-1224. doi: 10.1038/s41591-018-0137-0

Bak RO, Porteus MH. CRISPR-Mediated Integration of Large Gene Cassettes Using AAV Donor Vectors. Cell Reports. 2017 Jul 18;20(3):750-756. doi: 10.1016/j.celrep.2017.06.064

Bak RO, Dever DP, Reinisch A, Cruz Hernandez D, Majeti R, Porteus MH. Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6. eLife. 2017 Sept 28;6:e27873. doi: 10.7554/eLife.27873

Hollensen AK , Thomsen R , Bak RO , Petersen CC , Ermegaard ER , Aagaard L et al. Improved microRNA suppression by WPRE-linked Tough Decoy microRNA sponges. RNA. 2017 Aug;23(8):1247-1258. Epub 2017 May 9. doi: 10.1261/rna.061192.117

Dever DP, Bak RO, Reinisch A, Camarena J, Washington G, Nicolas CE et al. CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells. Nature. 2016 Nov 17;539(7629):384-389. doi: 10.1038/nature20134

Hnisz D, Weintraub AS, Day DS, Valton AL, Bak RO, Li CH et al. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science. 2016 Mar 25;351(6280):1454-1458. doi: 10.1126/science.aad9024

Holm CK , Rahbek SH , Gad HH , Bak RO , Jakobsen MR, Jiang Z et al. Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses. Nature Communications. 2016 Feb 19;7:10680. doi: 10.1038/ncomms10680

Hendel A, Bak RO, Clark JT, Kennedy AB, Ryan DE, Roy S et al. Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells. Nature Biotechnology. 2015 Jun 29. doi: 10.1038/nbt.3290

Rasmussen TK , Andersen T , Bak RO, Yiu G, Sørensen C , Stengaard-Pedersen K et al. Overexpression of MicroRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus. Arthritis research & therapy. 2015 Jun 9;17(1):154. doi: 10.1186/s13075-015-0660-z

Cai Y , Bak R , Mikkelsen JG. Targeted genome editing by lentiviral protein transduction of zinc-finger and TAL-effector nucleases. eLife. 2014 Apr 24;3:e01911. doi: 10.7554/eLife.01911

Bak RO , Hollensen AK , Mikkelsen JG. Managing MicroRNAs with Vector-Encoded Decoy-Type Inhibitors. Molecular Therapy. 2013 Aug;21(8):1478-85. doi: 10.1038/mt.2013.113

Bak R , Mikkelsen JG. miRNA sponges: soaking up miRNAs for regulation of gene expression. Wiley Interdisciplinary Reviews: RNA. 2013 Dec 23. doi: 10.1002/wrna.1213

Bak RO , Hollensen AK , Primo MN , Sørensen CD , Mikkelsen JG. Potent microRNA suppression by RNA Pol II-transcribed 'Tough Decoy' inhibitors. RNA. 2013;19(2):280-293. doi: 10.1261/rna.034850.112

Cai Y , Bak RO, Krogh LB, Staunstrup NH , Moldt B , Corydon TJ et al. DNA transposition by protein transduction of the piggyBac transposase from lentiviral Gag precursors. Nucleic Acids Research. 2013 Nov 21. doi: 10.1093/nar/gkt1163

Hollensen AK , Bak RO , Haslund D , Mikkelsen JG. Suppression of microRNAs by dual-targeting and clustered Tough Decoy inhibitors. RNA Biology. 2013;10(3).

Jakobsen MR , Bak RO, Andersen A, Berg RK , Jensen SB, Tengchuan J et al. IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. Proceedings of the National Academy of Sciences (PNAS). 2013 Oct 23. doi: 10.1073/pnas.1311669110

Kofod-Olsen E , Møller JM , Schleimann MH , Bundgaard B , Bak RO , Øster B et al. Inhibition of p53-dependent, but not p53-independent, cell death by U19 protein from human herpesvirus 6B. P L o S One. 2013;8(e59223):1-11.

Sharma N , Cai Y , Bak RO , Jakobsen MR , Schrøder LD , Mikkelsen JG. Efficient sleeping beauty DNA transposition from DNA minicircles. Molecular Therapy - Nucleic Acids. 2013;2:e74. doi: 10.1038/mtna.2013.1

Staunstrup NH , Bak RO , Cai Y, Svensson L, Petersen AT, Rosada C et al. A lentiviral vector-based genetic sensor system for comparative analysis of permeability and activity of vitamin D3 analogues in xenotransplanted human skin. Experimental Dermatology. 2013 Mar 22;22(3):178-83. doi: 10.1111/exd.12091

Nascimento Lopes Primo M , Bak RO , Mikkelsen JG. Lentiviral vectors for cutaneous RNA managing. Experimental Dermatology Online. 2012;21(3):162-70. doi: 10.1111/j.1600-0625.2011.01436.x

Nascimento Primo M , Bak RO, Schibler B, Mikkelsen JG. Regulation of pro-inflammatory cytokines TNFα and IL24 by microRNA-203 in primary keratinocytes. Cytokine. 2012. doi: 10.1016/j.cyto.2012.07.031

Sharma N , Hollensen AK , Bak RO , Staunstrup NH , Schrøder LD , Mikkelsen JG. The Impact of cHS4 Insulators on DNA Transposon Vector Mobilization and Silencing in Retinal Pigment Epithelium Cells. PLOS ONE. 2012;7(10). doi: 10.1371/journal.pone.0048421

Bak RO , Mikkelsen JG. Mobilization of DNA transposable elements from lentiviral vectors. Mobile Genetic Elements. 2011 Jul;1(2):139-144.

Bak RO , Stenderup K , Rosada C , Petersen LB , Moldt B , Dagnæs-Hansen F et al. Targeting of human interleukin-12B by small hairpin RNAs in xenografted psoriatic skin. B M C Dermatology. 2011 Feb 27;11(1):5. doi: 10.1186/1471-5945-11-5

Moldt B, Miskey C, Staunstrup NH, Gogol-Döring A, Bak RO , Sharma N et al. Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells. Molecular Therapy. 2011 Aug;19(8).

Staunstrup NH , Sharma N , Bak RO, Svensson L, Petersen TK, Aarenstrup L et al. A Sleeping Beauty DNA transposon-based genetic sensor for functional screening of vitamin D3 analogues. B M C Biotechnology. 2011 Apr 7;11(1):33. doi: 10.1186/1472-6750-11-33

Bak RO , Mikkelsen JG. Regulation of cytokines by small RNAs during skin inflammation. Journal of Biomedical Science. 2010;17(53).

Displaying results 51 to 77 out of 77

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Rasmus O. Bak